Colorectal cancer and self-reported tooth agenesis
نویسندگان
چکیده
منابع مشابه
Colorectal cancer and self-reported tooth agenesis
BACKGROUND Germline mutations in APC and AXIN2 are both associated with colon neoplasia as well as anomalous dental development. We tested the hypothesis that congenitally missing teeth may occur more commonly in individuals diagnosed with colorectal cancer than in individuals without this diagnosis. METHODS Via a survey conducted on 1636 individuals with colorectal cancer (CRC) and 2788 indi...
متن کاملMutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.
Wnt signaling regulates embryonic pattern formation and morphogenesis of most organs. Aberrations of regulation of Wnt signaling may lead to cancer. Here, we have used positional cloning to identify the causative mutation in a Finnish family in which severe permanent tooth agenesis (oligodontia) and colorectal neoplasia segregate with dominant inheritance. Eleven members of the family lacked at...
متن کاملTooth Agenesis
Tooth agenesis denotes a condition where teeth are missing due to a developmental failure. According to severity, this malformation can be subdivided into hypodontia, oligodontia and anodontia. With a frequency of 20–30%, tooth agenesis is the most prevalent dental dysplasia, but not all teeth are equally affected. Familial occurrence and concordance in twins indicate potential genetic causes. ...
متن کاملSelf-reported birth weight and subsequent risk of colorectal cancer.
Case series data suggest that high birth weight and neonatal macrosomia in offspring are associated with an increased risk of colorectal cancer in parents. We therefore conducted a prospective analysis investigating the association among self-reported birth weight, neonatal macrosomia, and incident colorectal cancer in a population-based study of men and women. Participants were drawn from a co...
متن کاملNonsyndromic cleft lip and palate, gastric cancer and tooth agenesis
BACKGROUND To determine the frequency of nonsyndromic cleft lip and/or palate (NSCL/P) in first-degree relatives and to analyze the prevalence of tooth agenesis in patients with gastric cancer. MATERIAL AND METHODS This cross-sectional, observational, case-control study included 798 patients attended at hospital Santa Casa in Montes Claros, Minas Gerais and Alfa Institute of Gastroenterology ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hereditary Cancer in Clinical Practice
سال: 2014
ISSN: 1897-4287
DOI: 10.1186/1897-4287-12-7